| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50389967 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835007 (CHEMBL2073499) |
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| IC50 | 54±n/a nM |
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| Citation |  Curtin, ML; Heyman, HR; Frey, RR; Marcotte, PA; Glaser, KB; Jankowski, JR; Magoc, TJ; Albert, DH; Olson, AM; Reuter, DR; Bouska, JJ; Montgomery, DA; Palma, JP; Donawho, CK; Stewart, KD; Tse, C; Michaelides, MR Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases. Bioorg Med Chem Lett22:4750-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50389967 |
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| n/a |
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| Name | BDBM50389967 |
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| Synonyms: | Aminopyrimidine (Scaffold VI) | CHEMBL1614709 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30FN7O |
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| Mol. Mass. | 451.5397 |
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| SMILES | CN1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cc1C |c:24| |
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| Structure | 
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