| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
|---|
| Ligand | BDBM50390102 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_834363 (CHEMBL2073279) |
|---|
| Ki | 17±n/a nM |
|---|
| Citation |  Watanabe, H; Ono, M; Kimura, H; Matsumura, K; Yoshimura, M; Okamoto, Y; Ihara, M; Takahashi, R; Saji, H Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease. Bioorg Med Chem Lett22:5700-3 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Microtubule-associated protein tau |
|---|
| Name: | Microtubule-associated protein tau |
|---|
| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 78928.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10636 |
|---|
| Residue: | 758 |
|---|
| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
|
|
|---|
| BDBM50390102 |
|---|
| n/a |
|---|
| Name | BDBM50390102 |
|---|
| Synonyms: | CHEMBL2069433 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15IN2O |
|---|
| Mol. Mass. | 390.2183 |
|---|
| SMILES | CN(C)c1ccc(\C=C2/Nc3ccc(I)cc3C2=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
