| Reaction Details |
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 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Ligand | BDBM50390258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835035 (CHEMBL2073527) |
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| IC50 | 12000±n/a nM |
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| Citation |  Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Discovery of potent and selective rhodanine type IKKß inhibitors by hit-to-lead strategy. Bioorg Med Chem Lett22:5668-74 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Synonyms: | IKKB_MOUSE | Ikbkb | Ikkb |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86687.79 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_835035 |
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| Residue: | 757 |
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| Sequence: | MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
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| BDBM50390258 |
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| n/a |
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| Name | BDBM50390258 |
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| Synonyms: | CHEMBL2070411 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32N4O4S2 |
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| Mol. Mass. | 588.74 |
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| SMILES | CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccccc4C(N)=O)cc3)C2=O)CC1 |
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| Structure | 
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