Ki Summary

Reaction Details

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Target

Inhibitor of nuclear factor kappa-B kinase subunit beta

Ligand

BDBM50149806

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_835035 (CHEMBL2073527)

IC50

1800±n/a nM

Citation

Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Discovery of potent and selective rhodanine type IKKß inhibitors by hit-to-lead strategy. Bioorg Med Chem Lett22:5668-74 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Inhibitor of nuclear factor kappa-B kinase subunit beta

Name:

Inhibitor of nuclear factor kappa-B kinase subunit beta

Synonyms:

IKKB_MOUSE | Ikbkb | Ikkb

Type:

PROTEIN

Mol. Mass.:

86687.79

Organism:

Mus musculus

Description:

ChEMBL_835035

Residue:

757

Sequence:

MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD

BDBM50149806

n/a

Name

BDBM50149806

Synonyms:

2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexahydro-[3,4'']bipyridinyl-3''-carbonitrile | 2-amino-6-(2-hydroxyphenyl)-4-(piperidin-3-yl)nicotinonitrile | CHEMBL360077

Type

Small organic molecule

Emp. Form.

C17H18N4O

Mol. Mass.

294.351

SMILES

Nc1nc(cc(C2CCCNC2)c1C#N)-c1ccccc1O

Structure