| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Ligand | BDBM50390269 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_835035 (CHEMBL2073527) |
|---|
| IC50 | 8000±n/a nM |
|---|
| Citation |  Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Discovery of potent and selective rhodanine type IKKß inhibitors by hit-to-lead strategy. Bioorg Med Chem Lett22:5668-74 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Synonyms: | IKKB_MOUSE | Ikbkb | Ikkb |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 86687.79 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_835035 |
|---|
| Residue: | 757 |
|---|
| Sequence: | MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
|
|
|
|---|
| BDBM50390269 |
|---|
| n/a |
|---|
| Name | BDBM50390269 |
|---|
| Synonyms: | CHEMBL2070424 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29N3O4S2 |
|---|
| Mol. Mass. | 547.688 |
|---|
| SMILES | CCN(CC)CCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3ccc(cc3)C(N)=O)cc2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
