| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50391374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_847933 (CHEMBL2150233) |
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| IC50 | >100000±n/a nM |
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| Citation |  Röhrig, UF; Majjigapu, SR; Grosdidier, A; Bron, S; Stroobant, V; Pilotte, L; Colau, D; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem55:5270-90 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47874.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_825691 |
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| Residue: | 406 |
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| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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| BDBM50391374 |
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| n/a |
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| Name | BDBM50391374 |
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| Synonyms: | CHEMBL2146496 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H5ClN4 |
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| Mol. Mass. | 180.594 |
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| SMILES | Clc1cc(ccn1)-c1c[nH]nn1 |
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| Structure | 
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