| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50300305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_847932 (CHEMBL2150232) |
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| IC50 | 60000±n/a nM |
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| Citation |  Röhrig, UF; Majjigapu, SR; Grosdidier, A; Bron, S; Stroobant, V; Pilotte, L; Colau, D; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem55:5270-90 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47757.90 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452150 |
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| Residue: | 406 |
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| Sequence: | MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSE
VKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVV
IFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHY
RDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLR
IQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
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| BDBM50300305 |
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| n/a |
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| Name | BDBM50300305 |
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| Synonyms: | 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL584991 | US10669273, Compound INCB024360 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7ClFN5O2 |
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| Mol. Mass. | 271.636 |
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| SMILES | Nc1nonc1C(NO)=Nc1ccc(F)c(Cl)c1 |w:9.10| |
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| Structure | 
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