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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50392242
Substrate/Competitorn/a
Meas. Tech.ChEMBL_850546 (CHEMBL2157768)
Kd 0.45±n/a nM
Citation Zhan, C; Zhao, L; Wei, X; Wu, X; Chen, X; Yuan, W; Lu, WY; Pazgier, M; Lu, W An ultrahigh affinity d-peptide antagonist Of MDM2. J Med Chem55:6237-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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  Blast E-value cutoff:
BDBM50392242
n/a
NameBDBM50392242
Synonyms:CHEMBL2153473
TypeSmall organic molecule
Emp. Form.C73H105F3N18O18
Mol. Mass.1579.7198
SMILESCC(C)C[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](Cc1ccc(cc1)C(F)(F)F)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)NC(=O)[C@H](N)[C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(O)=O |r,wU:95.100,88.92,62.72,49.54,25.30,8.12,101.104,wD:93.97,74.88,57.58,34.46,16.21,4.4,(33.04,-24.32,;33.04,-25.86,;34.37,-26.63,;31.7,-26.65,;31.7,-28.19,;30.37,-28.96,;29.03,-28.19,;29.03,-26.65,;27.7,-28.96,;27.71,-30.5,;29.04,-31.27,;29.04,-32.81,;30.37,-30.5,;26.36,-28.18,;25.03,-28.96,;25.04,-30.5,;23.7,-28.19,;23.7,-26.65,;25.04,-25.87,;25.04,-24.33,;26.37,-23.57,;26.36,-22,;22.37,-28.96,;21.03,-28.19,;21.03,-26.65,;19.7,-28.96,;19.7,-30.5,;21.03,-31.26,;21.03,-32.8,;19.7,-33.58,;22.37,-33.58,;18.36,-28.19,;17.02,-28.96,;17.02,-30.5,;15.69,-28.19,;15.69,-26.65,;17.02,-25.88,;17.02,-24.34,;18.36,-23.57,;19.69,-24.33,;19.69,-25.87,;18.36,-26.65,;21.02,-23.55,;22.36,-24.32,;21.02,-22.01,;22.35,-22.77,;14.36,-28.96,;13.02,-28.19,;13.03,-26.65,;11.68,-28.96,;11.69,-30.5,;13.03,-31.27,;14.36,-30.5,;13.03,-32.81,;10.35,-28.19,;9.02,-28.96,;9.02,-30.5,;7.68,-28.19,;7.68,-26.65,;6.35,-28.96,;5.02,-28.19,;5.02,-26.65,;3.68,-28.96,;3.68,-30.5,;5.02,-31.27,;6.35,-30.5,;7.68,-31.28,;7.68,-32.82,;9.02,-33.58,;6.35,-33.58,;5.02,-32.82,;2.34,-28.19,;1.01,-28.96,;1.01,-30.5,;-.32,-28.19,;-.32,-26.65,;1.02,-25.88,;2.42,-26.5,;3.45,-25.36,;2.67,-24.02,;3.15,-22.55,;2.12,-21.41,;.61,-21.74,;.14,-23.2,;1.17,-24.35,;-1.66,-28.96,;-2.99,-28.19,;-2.99,-26.65,;-4.33,-28.97,;-4.32,-30.51,;-5.65,-28.19,;-6.99,-28.97,;-6.99,-30.5,;-8.33,-28.19,;-9.66,-28.97,;-8.33,-26.65,;-9.66,-25.89,;-7,-25.89,;33.04,-28.96,;33.04,-30.5,;34.38,-28.18,;35.71,-28.95,;35.71,-30.5,;37.04,-31.26,;37.04,-32.79,;38.38,-33.57,;38.38,-35.11,;37.05,-35.89,;39.72,-35.89,;37.05,-28.19,;38.38,-28.96,;37.04,-26.64,)|
Structure
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