Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM50392256 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_850551 (CHEMBL2157773) |
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Ki | 5400±n/a nM |
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Citation | Hocková, D; Keough, DT; Janeba, Z; Wang, TH; de Jersey, J; Guddat, LW Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem55:6209-23 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM50392256 |
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n/a |
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Name | BDBM50392256 |
Synonyms: | CHEMBL2153494 |
Type | Small organic molecule |
Emp. Form. | C13H20N5O6P |
Mol. Mass. | 373.3016 |
SMILES | OC(=O)CCCN(CCn1cnc2c1nc[nH]c2=O)CCP(O)(O)=O |
Structure |
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