| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50392650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_854112 (CHEMBL2153943) |
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| IC50 | 800±n/a nM |
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| Citation |  Zhang, Z; Tian, C; Zhou, S; Wang, W; Guo, Y; Xia, J; Liu, Z; Wang, B; Wang, X; Golding, BT; Griff, RJ; Du, Y; Liu, J Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Eur J Med Chem58:228-36 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50392650 |
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| n/a |
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| Name | BDBM50392650 |
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| Synonyms: | CHEMBL2153704 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N7O5 |
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| Mol. Mass. | 455.4671 |
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| SMILES | Nc1nc(N)c2N3CN(CC3CCc2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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