Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM50392668 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_854158 (CHEMBL2154079) |
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IC50 | 1190±n/a nM |
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Citation | Biava, M; Battilocchio, C; Poce, G; Alfonso, S; Consalvi, S; Porretta, GC; Schenone, S; Calderone, V; Martelli, A; Testai, L; Ghelardini, C; Di Cesare Mannelli, L; Sautebin, L; Rossi, A; Giordani, A; Patrignani, P; Anzini, M Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme. Eur J Med Chem58:287-98 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
Type: | Protein |
Mol. Mass.: | 69020.39 |
Organism: | Mus musculus (Mouse) |
Description: | Q05769 |
Residue: | 604 |
Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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BDBM50392668 |
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n/a |
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Name | BDBM50392668 |
Synonyms: | CHEMBL2153830 |
Type | Small organic molecule |
Emp. Form. | C23H25FN2O5S |
Mol. Mass. | 460.518 |
SMILES | Cc1c(cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1)C(N)C(=O)OCCCO |
Structure |
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