Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM50392849 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_853362 (CHEMBL2155182) |
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IC50 | 1000±n/a nM |
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Citation | Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med Chem Lett3:721-725 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK-2 | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | MAP kinase 2 | MAPK 2 | MK01_RAT | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42-MAPK |
Type: | Enzyme |
Mol. Mass.: | 41278.65 |
Organism: | Rattus norvegicus (rat) |
Description: | MAP Kinase is the rat ERK-2 isoform containing a polyhistidine tag at the N-terminus produced in
E.coli. and activated by phosphorylation with MEK1 prior to purification. |
Residue: | 358 |
Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50392849 |
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n/a |
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Name | BDBM50392849 |
Synonyms: | CHEMBL2151190 | US9073941, 612 |
Type | Small organic molecule |
Emp. Form. | C14H11N5O4 |
Mol. Mass. | 313.2682 |
SMILES | Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc2OCOc2c1 |
Structure |
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