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TargetMatrix Metalloproteinase-8 (MMP-8)
LigandBDBM50215926
Substrate/Competitorn/a
Meas. Tech.ChEMBL_853825
IC50 0.39±n/a nM
Citation Shengule SRLoa-Kum-Cheung WLParish CRBlairvacq MMeijer LNakao YKaruso P A one-pot synthesis and biological activity of ageladine A and analogues. J Med Chem 54:2492-503 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix Metalloproteinase-8 (MMP-8)
Name:Collagenase
Synonyms:Collagenase 2 | MMP-8 | MMP8 | Matrix metalloproteinase-8 | Neutrophil collagenase | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (Human)
Description:n/a
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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  Blast E-value cutoff:
BDBM50215926
n/a
NameBDBM50215926
Synonyms:4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine | Ageladine A | CHEMBL230806
TypeSmall organic molecule
Emp. Form.C10H7Br2N5
Mol. Mass.357.004
SMILESNc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
Structure
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