| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 47 |
|---|
| Ligand | BDBM50393444 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_855560 (CHEMBL2162865) |
|---|
| EC50 | 530±n/a nM |
|---|
| Citation |  Weinstock, J; Wu, J; Cao, P; Kingsbury, WD; McDermott, JL; Kodrasov, MP; McKelvey, DM; Suresh Kumar, KG; Goldenberg, SJ; Mattern, MR; Nicholson, B Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. ACS Med Chem Lett3:789-792 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 47 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
|---|
| Synonyms: | Deubiquitinating enzyme 47 | UBP47_HUMAN | USP47 | Ubiquitin thioesterase 47 | Ubiquitin-specific-processing protease 47 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 157255.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_855560 |
|---|
| Residue: | 1375 |
|---|
| Sequence: | MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERI
TLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPG
KKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSIL
NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLF
VLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINEL
YQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPN
QYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF
IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGL
EKNSLIYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSS
GSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQR
EIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVK
YDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHV
VDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKT
LKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT
AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKST
ETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSD
ILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYD
ESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHF
KVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKF
LLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDI
NISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS
EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDK
TEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD
|
|
|
|---|
| BDBM50393444 |
|---|
| n/a |
|---|
| Name | BDBM50393444 |
|---|
| Synonyms: | CHEMBL2159503 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20Cl2N4O4S2 |
|---|
| Mol. Mass. | 527.444 |
|---|
| SMILES | CN(C)CCCOc1ccc(NC(=O)c2cc(c(Sc3c(Cl)cncc3Cl)s2)[N+]([O-])=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
