| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50394178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_856501 (CHEMBL2161547) |
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| IC50 | 19±n/a nM |
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| Citation |  Gopalsamy, A; Bennett, EM; Shi, M; Zhang, WG; Bard, J; Yu, K Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett22:6636-41 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50394178 |
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| n/a |
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| Name | BDBM50394178 |
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| Synonyms: | CHEMBL2158845 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N6O3S |
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| Mol. Mass. | 412.465 |
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| SMILES | NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2ccnc(c2)N2CCOCC2)c1 |
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| Structure | 
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