| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 6 |
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| Ligand | BDBM50394319 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_856936 (CHEMBL2160579) |
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| IC50 | >500000±n/a nM |
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| Citation |  Dosa, S; Stirnberg, M; Lülsdorff, V; Häußler, D; Maurer, E; Gütschow, M Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines. Bioorg Med Chem20:6489-505 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 6 |
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| Name: | Transmembrane protease serine 6 |
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| Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90001.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1442547 |
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| Residue: | 811 |
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| Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
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| BDBM50394319 |
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| n/a |
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| Name | BDBM50394319 |
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| Synonyms: | CHEMBL2159368 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3O4S |
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| Mol. Mass. | 335.378 |
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| SMILES | COc1ccc(NS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC |
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| Structure | 
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