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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50394524 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_855115 (CHEMBL2160873) | ||
| IC50 | 110±n/a nM | ||
| Citation |  Takeda, K; Terauchi, T; Hashizume, M; Shikata, K; Taguchi, R; Murata-Tai, K; Fujisawa, M; Takahashi, Y; Shin, K; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists. Bioorg Med Chem20:6559-78 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50394524 | |||
| n/a | |||
| Name | BDBM50394524 | ||
| Synonyms: | CHEMBL2160166 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H32N2O4 | ||
| Mol. Mass. | 424.5326 | ||
| SMILES | CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(3.37,8.06,;2.03,7.31,;2.01,5.77,;3.33,4.98,;4.69,5.72,;.67,5.01,;-.66,5.8,;-2,5.04,;-2.02,3.5,;-3.36,2.75,;-4.69,3.54,;-.69,2.72,;-.71,1.18,;.61,.39,;1.95,1.15,;3.28,.36,;1.97,2.69,;.65,3.47,;.59,-1.15,;-.75,-1.9,;-2.07,-1.11,;-3.42,-1.87,;-.77,-3.44,;.56,-4.23,;.54,-5.77,;-.8,-6.52,;-.82,-8.06,;1.9,-3.47,;1.92,-1.93,;3.26,-1.18,;4.58,-1.96,)| | ||
| Structure | 
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