Citation | Kosugi, T; Mitchell, DR; Fujino, A; Imai, M; Kambe, M; Kobayashi, S; Makino, H; Matsueda, Y; Oue, Y; Komatsu, K; Imaizumi, K; Sakai, Y; Sugiura, S; Takenouchi, O; Unoki, G; Yamakoshi, Y; Cunliffe, V; Frearson, J; Gordon, R; Harris, CJ; Kalloo-Hosein, H; Le, J; Patel, G; Simpson, DJ; Sherborne, B; Thomas, PS; Suzuki, N; Takimoto-Kamimura, M; Kataoka, K Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem55:6700-15 (2012) [PubMed] Article |
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SMILES | Cc1c(N[C@H]2CC[C@H](N)CC2)nc2ccnn2c1Nc1ccccc1Cl |r,wU:4.3,wD:7.7,(60.32,-84.65,;58.98,-85.42,;58.98,-86.96,;60.31,-87.73,;61.65,-86.96,;61.65,-85.43,;62.99,-84.67,;64.32,-85.44,;65.66,-84.68,;64.31,-86.98,;62.98,-87.75,;57.65,-87.72,;56.32,-86.96,;54.85,-87.44,;53.94,-86.18,;54.85,-84.93,;56.32,-85.41,;57.65,-84.64,;57.65,-83.1,;56.32,-82.33,;55,-83.09,;53.67,-82.32,;53.67,-80.78,;55,-80.01,;56.33,-80.78,;57.67,-80.02,)| |