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TargetKCNQ (Kv7) potassium channel
LigandBDBM50395464
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858522
IC50 200±n/a nM
Citation Cheung YYYu HXu KZou BWu MMcManus OBLi MLindsley CWHopkins CR Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem 55:6975-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
KCNQ (Kv7) potassium channel
Name:KCNQ (Kv7) potassium channel
Synonyms:KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:PROTEIN
Mol. Mass.:77131.10
Organism:Homo sapiens (Human)
Description:ChEMBL_1520985
Residue:695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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  Blast E-value cutoff:
BDBM50395464
n/a
NameBDBM50395464
Synonyms:CHEMBL2164048
TypeSmall organic molecule
Emp. Form.C20H24N2O
Mol. Mass.308.4174
SMILESCC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 |r|
Structure
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