| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 4 |
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| Ligand | BDBM50395464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_858522 (CHEMBL2169526) |
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| IC50 | 200±n/a nM |
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| Citation |  Cheung, YY; Yu, H; Xu, K; Zou, B; Wu, M; McManus, OB; Li, M; Lindsley, CW; Hopkins, CR Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem55:6975-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 4 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 4 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77131.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1520985 |
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| Residue: | 695 |
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| Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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| BDBM50395464 |
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| n/a |
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| Name | BDBM50395464 |
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| Synonyms: | CHEMBL2164048 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O |
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| Mol. Mass. | 308.4174 |
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| SMILES | CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 |r| |
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| Structure | 
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