Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50130274 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_861106 (CHEMBL2166697) |
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Ki | 2.3±n/a nM |
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Citation | Nirogi, RV; Konda, JB; Kambhampati, R; Shinde, A; Bandyala, TR; Gudla, P; Kandukuri, KK; Jayarajan, P; Kandikere, V; Dubey, PK N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett22:6980-5 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50130274 |
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n/a |
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Name | BDBM50130274 |
Synonyms: | (9-Benzenesulfonyl-6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-4-ylmethyl)-dimethyl-amine | CHEMBL92093 |
Type | Small organic molecule |
Emp. Form. | C22H26N2O3S |
Mol. Mass. | 398.518 |
SMILES | COc1ccc2n(c3CCCC(CN(C)C)c3c2c1)S(=O)(=O)c1ccccc1 |
Structure |
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