| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50396101 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_865008 (CHEMBL2176172) |
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| IC50 | >30000±n/a nM |
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| Citation |  Zhang, Y; Clark, JA; Connelly, MC; Zhu, F; Min, J; Guiguemde, WA; Pradhan, A; Iyer, L; Furimsky, A; Gow, J; Parman, T; El Mazouni, F; Phillips, MA; Kyle, DE; Mirsalis, J; Guy, RK Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. J Med Chem55:4205-19 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65581.88 |
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| Organism: | Plasmodium falciparum |
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| Description: | His6-tag DHODH was expressed in E. coli. |
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| Residue: | 569 |
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| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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| BDBM50396101 |
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| n/a |
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| Name | BDBM50396101 |
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| Synonyms: | CHEMBL2170884 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20FNO5 |
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| Mol. Mass. | 433.4284 |
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| SMILES | CCOC(=O)c1c(O)c2cc(F)c(OC)cc2nc1-c1cccc(Oc2ccccc2)c1 |
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| Structure | 
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