| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
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| Ligand | BDBM20283 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863016 (CHEMBL2175196) |
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| IC50 | 86000±n/a nM |
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| Citation |  Debnath, B; Xu, S; Neamati, N Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem55:6645-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 3 |
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| Name: | Signal transducer and activator of transcription 3 |
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| Synonyms: | Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3 |
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| Type: | Cytosolic Transcription Factor |
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| Mol. Mass.: | 88050.28 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Bacterially expressed protein was used in the FP assay. |
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| Residue: | 770 |
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| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
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| BDBM20283 |
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| n/a |
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| Name | BDBM20283 |
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| Synonyms: | 2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}acetamido)benzoic acid | NSC 74859 | S3I-201 | cid_252682 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO7S |
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| Mol. Mass. | 365.358 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1 |
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| Structure | 
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