| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
|---|
| Ligand | BDBM50396171 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_862995 (CHEMBL2175175) |
|---|
| IC50 | 114000±n/a nM |
|---|
| Citation |  Debnath, B; Xu, S; Neamati, N Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem55:6645-68 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 3 |
|---|
| Name: | Signal transducer and activator of transcription 3 |
|---|
| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88064.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P40763 |
|---|
| Residue: | 770 |
|---|
| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
|
|
|
|---|
| BDBM50396171 |
|---|
| n/a |
|---|
| Name | BDBM50396171 |
|---|
| Synonyms: | CHEMBL2172009 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17ClN2O5S |
|---|
| Mol. Mass. | 432.877 |
|---|
| SMILES | [#6]-[#6]-[#7]-1-[#6](=S)-[#7](-[#6]-[#6])-[#6](=O)\[#6](=[#6]\c2ccc(o2)-c2cc(ccc2Cl)-[#6](-[#8])=O)-[#6]-1=O |
|---|
| Structure | 
|
|---|
Search and Browse
