| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
|---|
| Ligand | BDBM50396182 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_863007 (CHEMBL2175187) |
|---|
| IC50 | 90000±n/a nM |
|---|
| Citation |  Debnath, B; Xu, S; Neamati, N Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem55:6645-68 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 3 |
|---|
| Name: | Signal transducer and activator of transcription 3 |
|---|
| Synonyms: | Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3 |
|---|
| Type: | Cytosolic Transcription Factor |
|---|
| Mol. Mass.: | 88050.28 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Bacterially expressed protein was used in the FP assay. |
|---|
| Residue: | 770 |
|---|
| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
|
|
|
|---|
| BDBM50396182 |
|---|
| n/a |
|---|
| Name | BDBM50396182 |
|---|
| Synonyms: | CHEMBL2172016 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21N2O7P |
|---|
| Mol. Mass. | 480.4065 |
|---|
| SMILES | COc1cccc(NC(=O)c2nc(oc2Cc2ccc(OP(O)(O)=O)cc2)-c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
