| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal protective protein |
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| Ligand | BDBM50396575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863255 (CHEMBL2176198) |
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| IC50 | 200±n/a nM |
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| Citation |  Ruf, S; Buning, C; Schreuder, H; Horstick, G; Linz, W; Olpp, T; Pernerstorfer, J; Hiss, K; Kroll, K; Kannt, A; Kohlmann, M; Linz, D; Hübschle, T; Rütten, H; Wirth, K; Schmidt, T; Sadowski, T Novelß-amino acid derivatives as inhibitors of cathepsin A. J Med Chem55:7636-49 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal protective protein |
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| Name: | Lysosomal protective protein |
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| Synonyms: | CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 54465.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10619 |
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| Residue: | 480 |
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| Sequence: | MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
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| BDBM50396575 |
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| n/a |
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| Name | BDBM50396575 |
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| Synonyms: | CHEMBL2171606 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21N3O5 |
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| Mol. Mass. | 443.4513 |
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| SMILES | OC(=O)CC(NC(=O)c1cc(=O)n([nH]1)-c1ccccc1)c1ccc(Oc2ccccc2)cc1 |
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| Structure | 
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