Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50396567 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_863254 (CHEMBL2176197) |
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IC50 | 300±n/a nM |
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Citation | Ruf, S; Buning, C; Schreuder, H; Horstick, G; Linz, W; Olpp, T; Pernerstorfer, J; Hiss, K; Kroll, K; Kannt, A; Kohlmann, M; Linz, D; Hübschle, T; Rütten, H; Wirth, K; Schmidt, T; Sadowski, T Novelß-amino acid derivatives as inhibitors of cathepsin A. J Med Chem55:7636-49 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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BDBM50396567 |
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n/a |
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Name | BDBM50396567 |
Synonyms: | CHEMBL2171387 |
Type | Small organic molecule |
Emp. Form. | C19H14Cl3N3O4 |
Mol. Mass. | 454.691 |
SMILES | OC(=O)CC(NC(=O)c1cc(=O)n([nH]1)-c1ccc(Cl)cc1)c1cc(Cl)ccc1Cl |
Structure |
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