Reaction Details |
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Target | Oxysterols receptor LXR-alpha |
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Ligand | BDBM50396601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_863934 (CHEMBL2176511) |
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IC50 | 4100±n/a nM |
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Citation | Aoyama, A; Endo-Umeda, K; Kishida, K; Ohgane, K; Noguchi-Yachide, T; Aoyama, H; Ishikawa, M; Miyachi, H; Makishima, M; Hashimoto, Y Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton. J Med Chem55:7360-77 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxysterols receptor LXR-alpha |
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Name: | Oxysterols receptor LXR-alpha |
Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50403.85 |
Organism: | Homo sapiens (Human) |
Description: | Q13133 |
Residue: | 447 |
Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50396601 |
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n/a |
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Name | BDBM50396601 |
Synonyms: | CHEMBL2171902 |
Type | Small organic molecule |
Emp. Form. | C16H13NO2 |
Mol. Mass. | 251.2799 |
SMILES | CN1c2ccc(O)cc2C(=C)c2ccccc2C1=O |
Structure |
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