| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) |
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| Ligand | BDBM50396731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864305 |
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| Ki | 4000±n/a nM |
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| Citation |  Brožic P; Turk S; Adeniji AO; Konc J; Janežic D; Penning TM; Lanišnik Rižner T; Gobec S Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library. J Med Chem 55:7417-24 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) |
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| Name: | Aldo-keto-reductase family 1 member C3 |
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| Synonyms: | 3-alpha-HSD type 2 | Aldo-keto reductase family 1 member C3 | Aldo-keto reductase family 1 member C3 (AK1C3) | Aldo-keto reductase family 1 member C3 (AK1C3a) | Aldo-keto reductase family 1 member C3 (AKR1C3) | Dihydrodiol dehydrogenase 3 | Dihydrodiol dehydrogenase type I | Estradiol 17-beta-dehydrogenase | Prostaglandin F synthase | Testosterone 17-beta-dehydrogenase 5 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 36859.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42330 |
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| Residue: | 323 |
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| Sequence: | MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
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| BDBM50396731 |
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| n/a |
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| Name | BDBM50396731 |
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| Synonyms: | CHEMBL2172254 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10O5 |
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| Mol. Mass. | 270.2369 |
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| SMILES | OC(=O)COc1ccc2c(c1)oc(=O)c1ccccc21 |
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| Structure | 
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