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TargetProstaglandin E synthase
LigandBDBM50397238
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864584
IC50 6400±n/a nM
Citation Elkady MNieß RSchaible AMBauer JLuderer SAmbrosi GWerz OLaufer SA Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX. J Med Chem 55:8958-62 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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  Blast E-value cutoff:
BDBM50397238
n/a
NameBDBM50397238
Synonyms:CHEMBL2172786
TypeSmall organic molecule
Emp. Form.C26H23ClN2O5S
Mol. Mass.510.989
SMILESCOc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NS(=O)(=O)c3ccc(C)cc3)c2c1
Structure
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