| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50397419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864983 (CHEMBL2176057) |
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| EC50 | 35±n/a nM |
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| Citation |  Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem55:8859-78 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50397419 |
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| n/a |
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| Name | BDBM50397419 |
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| Synonyms: | CHEMBL2170562 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28N2O6 |
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| Mol. Mass. | 500.5424 |
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| SMILES | COc1ccc(cc1)[C@@]12Oc3cc(cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C)C#N |r| |
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| Structure | 
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