| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50397441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864984 (CHEMBL2176058) |
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| EC50 | >5000±n/a nM |
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| Citation |  Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem55:8859-78 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50397441 |
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| n/a |
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| Name | BDBM50397441 |
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| Synonyms: | CHEMBL2170707 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28O7 |
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| Mol. Mass. | 476.5177 |
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| SMILES | COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(C)cc3OC |r| |
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| Structure | 
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