| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50397448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864990 (CHEMBL2176154) |
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| IC50 | 800±n/a nM |
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| Citation |  Pokhrel, L; Maezawa, I; Nguyen, TD; Chang, KO; Jin, LW; Hua, DH Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules. J Med Chem55:8969-73 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT |
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| Type: | Multi-pass membrane protein may form homo- or heterodimers. |
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| Mol. Mass.: | 64751.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35610 |
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| Residue: | 550 |
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| Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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| BDBM50397448 |
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| n/a |
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| Name | BDBM50397448 |
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| Synonyms: | CHEMBL2170728 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29NO4 |
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| Mol. Mass. | 431.5235 |
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| SMILES | CC(CNCc1ccc(O)c2ccccc12)[C@H]1CCC2=Cc3c(O[C@H]2C1)cc(C)oc3=O |r,t:21| |
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| Structure | 
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