Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM50097346 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_862249 (CHEMBL2172930) |
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IC50 | 3900±n/a nM |
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Citation | Favia, AD; Habrant, D; Scarpelli, R; Migliore, M; Albani, C; Bertozzi, SM; Dionisi, M; Tarozzo, G; Piomelli, D; Cavalli, A; De Vivo, M Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem55:8807-26 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 |
Type: | Enzyme |
Mol. Mass.: | 69003.89 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI). |
Residue: | 604 |
Sequence: | MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
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BDBM50097346 |
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n/a |
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Name | BDBM50097346 |
Synonyms: | (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid(carprofen) | 2-(6-chloro-9H-carbazol-2-yl)propanoic acid | CARPROFEN | CHEMBL1316 | Rimadyl | Ro-20-5720/000 |
Type | Small organic molecule |
Emp. Form. | C15H12ClNO2 |
Mol. Mass. | 273.714 |
SMILES | CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21 |
Structure |
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