Compile Data Set for Download or QSAR

Found 1287 hits with Last Name = 'migliore' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50153378 (CHEMBL3775041 | US9630914, Compound 12) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O Show InChI InChI=1S/C22H26FNO4/c1-3-4-5-6-12-24-22(27)28-18-9-7-8-17(13-18)19-11-10-16(14-20(19)23)15(2)21(25)26/h7-11,13-15H,3-6,12H2,1-2H3,(H,24,27)(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna US Patent					Assay Description COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...				US Patent US9630914 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H0S
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612206 (CHEMBL5277668) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:37| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612227 (CHEMBL5289675) Show SMILES C[C@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612226 (CHEMBL5281154) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612225 (CHEMBL5286893) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccncc4)c3c2)=C(C)N(C)c2nnnn12 |r,t:23| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612209 (CHEMBL5288427) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)=C1C |c:34| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612208 (CHEMBL5284027) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4ccc(cc4)S(N)(=O)=O)c3c2)=C1C |c:34| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612231 (CHEMBL5280373) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)=C1C |c:32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612226 (CHEMBL5281154) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612206 (CHEMBL5277668) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:37| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612225 (CHEMBL5286893) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccncc4)c3c2)=C(C)N(C)c2nnnn12 |r,t:23| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50153360 (CHEMBL3774784) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)[C@H](C)C(O)=O |r| Show InChI InChI=1S/C22H26FNO4/c1-3-4-5-6-12-24-22(27)28-18-9-7-8-17(13-18)19-11-10-16(14-20(19)23)15(2)21(25)26/h7-11,13-15H,3-6,12H2,1-2H3,(H,24,27)(H,25,26)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612207 (CHEMBL5274608) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4cc(ncn4)N4CCOCC4)c3c2)=C1C |c:37| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612205 (CHEMBL5279036) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4ccncc4)c3c2)=C1C |c:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612209 (CHEMBL5288427) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)=C1C |c:34| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612208 (CHEMBL5284027) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4ccc(cc4)S(N)(=O)=O)c3c2)=C1C |c:34| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612229 (CHEMBL5280577) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(C)c3c2)=C1C |c:26| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612223 (CHEMBL5279816) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(C)c3c2)=C(C)N(C)c2nnnn12 |r,t:17| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612207 (CHEMBL5274608) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(-c4cc(ncn4)N4CCOCC4)c3c2)=C1C |c:37| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612227 (CHEMBL5289675) Show SMILES C[C@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612226 (CHEMBL5281154) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612221 (CHEMBL5289513) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]ncc3c2)=C(C)N(C)c2nnnn12 |r,t:16| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
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Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM26739 (3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612231 (CHEMBL5280373) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)=C1C |c:32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612226 (CHEMBL5281154) Show SMILES C[C@@H]1C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C(C)N(C)c2nnnn12 |r,t:30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612210 (CHEMBL5271931) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(Br)c3c2)=C1C |c:24| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612231 (CHEMBL5280373) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)=C1C |c:32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153438 (CHEMBL3774873 | US9630914, Example 14) Show SMILES CCCCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O Show InChI InChI=1S/C9H12N2O2S/c1-14(12,13)6-7-2-4-8(5-3-7)9(10)11/h2-5H,6H2,1H3,(H3,10,11)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna US Patent					Assay Description Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...				US Patent US9630914 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H0S
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Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612219 (CHEMBL5286615) Show SMILES CC1=C(Cn2nnnc2N1c1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153438 (CHEMBL3774873 | US9630914, Example 14) Show SMILES CCCCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O Show InChI InChI=1S/C9H12N2O2S/c1-14(12,13)6-7-2-4-8(5-3-7)9(10)11/h2-5H,6H2,1H3,(H3,10,11)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153356 (CHEMBL3774686) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1)C(C)C(O)=O Show InChI InChI=1S/C22H27NO4/c1-3-4-5-6-14-23-22(26)27-20-9-7-8-19(15-20)18-12-10-17(11-13-18)16(2)21(24)25/h7-13,15-16H,3-6,14H2,1-2H3,(H,23,26)(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50511300 (CHEMBL4580541) Show SMILES O=C(NCCCCc1ccccc1)n1c2ccncc2oc1=O Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-9-11-18-12-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...				J Med Chem 63: 3634-3664 (2020) Article DOI: 10.1021/acs.jmedchem.9b02004 BindingDB Entry DOI: 10.7270/Q20C503N
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612212 (CHEMBL5288038) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(NC(=O)c4ccccc4)c3c2)=C1C |c:33| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153445 (CHEMBL3775280 | US9630914, Example 15) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)CO Show InChI InChI=1S/C9H12N2O/c10-9(11)8-3-1-7(2-4-8)5-6-12/h1-4,12H,5-6H2,(H3,10,11)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612231 (CHEMBL5280373) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)=C1C |c:32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153445 (CHEMBL3775280 | US9630914, Example 15) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)CO Show InChI InChI=1S/C9H12N2O/c10-9(11)8-3-1-7(2-4-8)5-6-12/h1-4,12H,5-6H2,(H3,10,11)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna US Patent					Assay Description Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...				US Patent US9630914 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H0S
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50153438 (CHEMBL3774873 | US9630914, Example 14) Show SMILES CCCCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O Show InChI InChI=1S/C9H12N2O2S/c1-14(12,13)6-7-2-4-8(5-3-7)9(10)11/h2-5H,6H2,1H3,(H3,10,11)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna US Patent					Assay Description Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...				US Patent US9630914 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H0S
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612230 (CHEMBL5270706) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(c4)N4CCOCC4)c3c2)=C1C |c:39| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50556798 (CHEMBL4742096) Show SMILES Clc1ccc(cc1)-c1coc(=O)n1C(=O)NCCCCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01561 BindingDB Entry DOI: 10.7270/Q2G73JC2
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50153354 (CHEMBL3775510) Show SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1C(F)(F)F)C(C)C(O)=O Show InChI InChI=1S/C23H26F3NO4/c1-3-4-5-6-12-27-22(30)31-18-9-7-8-17(13-18)19-11-10-16(15(2)21(28)29)14-20(19)23(24,25)26/h7-11,13-15H,3-6,12H2,1-2H3,(H,27,30)(H,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...				Eur J Med Chem 109: 216-37 (2016) Article DOI: 10.1016/j.ejmech.2015.12.036 BindingDB Entry DOI: 10.7270/Q21C1ZRJ
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612219 (CHEMBL5286615) Show SMILES CC1=C(Cn2nnnc2N1c1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acid ceramidase (Homo sapiens (Human))	BDBM50511282 (CHEMBL4592427) Show SMILES O=C(NCCCCc1ccccc1)n1c2cnccc2oc1=O Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-12-18-11-9-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...				J Med Chem 63: 3634-3664 (2020) Article DOI: 10.1021/acs.jmedchem.9b02004 BindingDB Entry DOI: 10.7270/Q20C503N
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50153379 (CHEMBL3775979 | US9630914, Example 13) Show SMILES CCCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O Show InChI InChI=1S/C23H28FNO4/c1-3-4-5-6-7-13-25-23(28)29-19-10-8-9-18(14-19)20-12-11-17(15-21(20)24)16(2)22(26)27/h8-12,14-16H,3-7,13H2,1-2H3,(H,25,28)(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna US Patent					Assay Description Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...				US Patent US9630914 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H0S
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612211 (CHEMBL5266676) Show SMILES CN1c2nnnn2CC(C(=O)Nc2ccc3[nH]nc(C(N)=O)c3c2)=C1C |c:26| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50612231 (CHEMBL5280373) Show SMILES CN1c2nnnn2C(C)(C)C(C(=O)Nc2ccc3[nH]nc(-c4ccccc4)c3c2)=C1C |c:32| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair

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