| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50398078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_873904 (CHEMBL2184740) |
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| IC50 | 14000±n/a nM |
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| Citation |  Madsen, JL; Andersen, TL; Santamaria, S; Nagase, H; Enghild, JJ; Skrydstrup, T Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase. J Med Chem55:7900-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50398078 |
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| n/a |
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| Name | BDBM50398078 |
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| Synonyms: | CHEMBL2182019 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H44N4O4 |
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| Mol. Mass. | 524.6948 |
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| SMILES | CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)Cc1ccc2ccccc2c1)[C@@H](C)CC |r| |
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| Structure | 
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