| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50399079 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878776 (CHEMBL2183716) |
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| Ki | 610±n/a nM |
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| Citation |  Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibita- andß-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms. J Med Chem55:9619-29 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | β-Carbonic anhydrase 2 (CA 2) | Carbonic anhydrase | MTCA2_MYCTU | canB | cynT | mtcA2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 21788.97 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WPJ9 |
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| Residue: | 207 |
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| Sequence: | MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEI
IFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDG
TLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSL
AIVGVTYQLDDGRAVLRDHIGNIGEEV
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| BDBM50399079 |
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| n/a |
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| Name | BDBM50399079 |
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| Synonyms: | CHEMBL2179308 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O3S2 |
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| Mol. Mass. | 373.449 |
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| SMILES | COc1ccc2-c3c(CSc2c1)cnn3-c1ccc(cc1)S(N)(=O)=O |
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| Structure | 
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