| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM50399403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877886 (CHEMBL2188143) |
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| IC50 | 180±n/a nM |
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| Citation |  Gerusz, V; Denis, A; Faivre, F; Bonvin, Y; Oxoby, M; Briet, S; LeFralliec, G; Oliveira, C; Desroy, N; Raymond, C; Peltier, L; Moreau, F; Escaich, S; Vongsouthi, V; Floquet, S; Drocourt, E; Walton, A; Prouvensier, L; Saccomani, M; Durant, L; Genevard, JM; Sam-Sambo, V; Soulama-Mouze, C From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. J Med Chem55:9914-28 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 27989.00 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q6GI75 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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| BDBM50399403 |
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| n/a |
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| Name | BDBM50399403 |
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| Synonyms: | CHEMBL2178288 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12F2O4 |
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| Mol. Mass. | 294.2502 |
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| SMILES | CCc1cc(O)c(Oc2ccc(cc2F)C(O)=O)cc1F |
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| Structure | 
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