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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM50399684
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789
IC50 430±n/a nM
Citation Barlind JGBauer UABirch AMBirtles SBuckett LKButlin RJDavies RDEriksson JWHammond CDHovland RJohannesson PJohansson MJKemmitt PDLindmark BTMorentin Gutierrez PNoeske TANordin AO'Donnell CJPetersson AURedzic ATurnbull AVVinblad J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem 55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1 (DGAT1)
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50399684
n/a
NameBDBM50399684
Synonyms:CHEMBL2178944
TypeSmall organic molecule
Emp. Form.C21H25N3O3
Mol. Mass.367.4415
SMILESCc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.18,20.22,(39.9,-10.55,;41.23,-9.78,;42.57,-10.55,;43.9,-9.77,;45.24,-10.54,;43.9,-8.24,;42.57,-7.47,;41.23,-8.23,;39.9,-7.46,;38.56,-8.23,;39.9,-5.92,;45.23,-7.47,;46.56,-8.24,;47.9,-7.47,;47.9,-5.92,;46.56,-5.16,;45.23,-5.93,;49.23,-5.15,;50.57,-5.92,;51.89,-5.15,;51.89,-3.61,;53.23,-2.84,;54.56,-3.61,;55.9,-2.84,;54.56,-5.15,;50.56,-2.84,;49.22,-3.61,)|
Structure
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