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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50399703
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789 (CHEMBL2183606)
IC50 410±n/a nM
Citation Barlind, JG; Bauer, UA; Birch, AM; Birtles, S; Buckett, LK; Butlin, RJ; Davies, RD; Eriksson, JW; Hammond, CD; Hovland, R; Johannesson, P; Johansson, MJ; Kemmitt, PD; Lindmark, BT; Morentin Gutierrez, P; Noeske, TA; Nordin, A; O'Donnell, CJ; Petersson, AU; Redzic, A; Turnbull, AV; Vinblad, J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM50399703
n/a
NameBDBM50399703
Synonyms:CHEMBL2178388
TypeSmall organic molecule
Emp. Form.C21H23F2N3O3
Mol. Mass.403.4224
SMILESCc1nc(C(F)F)c(nc1-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1)C(N)=O |r,wU:16.17,wD:19.21,(46.43,-53.65,;45.1,-52.89,;43.77,-53.66,;42.43,-52.89,;41.1,-53.66,;39.76,-52.89,;41.1,-55.2,;42.43,-51.35,;43.76,-50.58,;45.1,-51.35,;46.43,-50.58,;47.76,-51.35,;49.1,-50.58,;49.09,-49.03,;47.76,-48.27,;46.43,-49.04,;50.43,-48.26,;50.42,-46.72,;51.76,-45.95,;53.09,-46.72,;54.43,-45.95,;55.76,-46.72,;57.09,-45.95,;55.76,-48.26,;53.09,-48.26,;51.76,-49.03,;41.1,-50.57,;39.76,-51.34,;41.1,-49.03,)|
Structure
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