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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 1 | ||
| Ligand | BDBM50399712 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_876785 (CHEMBL2183602) | ||
| IC50 | >33000±n/a nM | ||
| Citation |  Barlind, JG; Bauer, UA; Birch, AM; Birtles, S; Buckett, LK; Butlin, RJ; Davies, RD; Eriksson, JW; Hammond, CD; Hovland, R; Johannesson, P; Johansson, MJ; Kemmitt, PD; Lindmark, BT; Morentin Gutierrez, P; Noeske, TA; Nordin, A; O'Donnell, CJ; Petersson, AU; Redzic, A; Turnbull, AV; Vinblad, J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem55:10610-29 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 1 | |||
| Name: | Sterol O-acyltransferase 1 | ||
| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
| Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
| Mol. Mass.: | 64751.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35610 | ||
| Residue: | 550 | ||
| Sequence: |
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| BDBM50399712 | |||
| n/a | |||
| Name | BDBM50399712 | ||
| Synonyms: | CHEMBL2178951 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N3O3 | ||
| Mol. Mass. | 353.4149 | ||
| SMILES | Cc1ncc(nc1-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1)C(N)=O |r,wU:13.14,wD:16.18,(28.53,-10.23,;27.19,-9.46,;25.86,-10.23,;24.52,-9.46,;24.52,-7.92,;25.86,-7.15,;27.19,-7.93,;28.52,-7.16,;29.86,-7.93,;31.19,-7.16,;31.19,-5.61,;29.85,-4.84,;28.52,-5.62,;32.52,-4.84,;32.51,-3.3,;33.85,-2.53,;35.19,-3.3,;36.52,-2.53,;37.85,-3.3,;39.19,-2.53,;37.85,-4.84,;35.18,-4.84,;33.86,-5.61,;23.19,-7.15,;21.86,-7.92,;23.19,-5.61,)| | ||
| Structure | 
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