Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50400512

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_879545 (CHEMBL2208954)

0.4±n/a nM

Citation

Chen, J; Collins, GT; Levant, B; Woods, J; Deschamps, JR; Wang, S CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist. ACS Med Chem Lett2:620-625 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3

Type:

Protein

Mol. Mass.:

49540.58

Organism:

Rattus norvegicus (Rat)

Description:

P19020

Residue:

446

Sequence:

MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC

BDBM50400512

n/a

Name

BDBM50400512

Synonyms:

CHEMBL2203405

Type

Small organic molecule

Emp. Form.

C27H34N4O2S

Mol. Mass.

478.649

SMILES

CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.11,6.6,wD:24.26,6.5,(37,-43.99,;37,-42.44,;35.67,-41.67,;35.67,-40.13,;37.01,-39.36,;38.34,-40.14,;39.67,-39.37,;39.66,-40.91,;41.16,-39.77,;41.56,-38.29,;40.07,-37.89,;42.9,-37.52,;44.23,-38.3,;44.22,-39.84,;45.59,-37.56,;45.59,-36.03,;46.91,-35.26,;48.23,-36.02,;49.56,-35.25,;50.9,-36.03,;50.89,-37.57,;49.56,-38.33,;48.23,-37.55,;46.92,-38.32,;34.34,-39.36,;34.34,-37.82,;33.01,-37.04,;31.68,-37.81,;30.21,-37.33,;29.3,-38.59,;27.76,-38.59,;30.21,-39.84,;31.68,-39.36,;33.01,-40.12,)|

Structure