| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Ligand | BDBM50156760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_880330 (CHEMBL2209185) |
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| IC50 | 48900±n/a nM |
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| Citation |  Maurer, B; Rumpf, T; Scharfe, M; Stolfa, DA; Schmitt, ML; He, W; Verdin, E; Sippl, W; Jung, M Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett3:1050-1053 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Name: | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5 |
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| Type: | Protein |
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| Mol. Mass.: | 33892.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXA8 |
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| Residue: | 310 |
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| Sequence: | MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAG
VSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRA
IAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPI
CPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA
HCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEA
LACHENETVS
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| BDBM50156760 |
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| n/a |
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| Name | BDBM50156760 |
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| Synonyms: | (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide | 2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide | CHEMBL380797 | Sirtinol |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N2O2 |
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| Mol. Mass. | 394.4651 |
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| SMILES | CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 |
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| Structure | 
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