Ki Summary

Reaction Details

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Target

Prostaglandin D2 receptor 2

Ligand

BDBM50401100

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_884446 (CHEMBL2212208)

IC50

>1000±n/a nM

Citation

Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin D2 receptor 2

Name:

Prostaglandin D2 receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

43295.45

Organism:

Homo sapiens (Human)

Description:

Q9Y5Y4

Residue:

395

Sequence:

MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

BDBM50401100

n/a

Name

BDBM50401100

Synonyms:

CHEMBL2205156

Type

Small organic molecule

Emp. Form.

C26H23N3O2

Mol. Mass.

409.4797

SMILES

Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CCO |(39.21,-35.7,;37.67,-35.7,;36.75,-34.45,;37.53,-33.12,;39.07,-33.13,;39.84,-31.8,;41.38,-31.81,;42.15,-33.15,;41.37,-34.47,;42.13,-35.8,;43.67,-35.81,;44.44,-34.47,;43.68,-33.14,;39.08,-30.47,;39.85,-29.14,;37.54,-30.46,;36.76,-29.13,;35.22,-29.13,;34.45,-30.48,;35.22,-31.81,;36.76,-31.8,;35.28,-34.93,;33.94,-34.17,;32.62,-34.94,;32.61,-36.48,;33.95,-37.25,;35.28,-36.48,;36.75,-36.96,;37.23,-38.42,;36.2,-39.57,;34.69,-39.25,)|

Structure