Ki Summary

Reaction Details

Report a problem with these data

Target

Prostaglandin D2 receptor 2

Ligand

BDBM50401102

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_884446 (CHEMBL2212208)

IC50

>1000±n/a nM

Citation

Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin D2 receptor 2

Name:

Prostaglandin D2 receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

43295.45

Organism:

Homo sapiens (Human)

Description:

Q9Y5Y4

Residue:

395

Sequence:

MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

BDBM50401102

n/a

Name

BDBM50401102

Synonyms:

CHEMBL2205154

Type

Small organic molecule

Emp. Form.

C27H24N4O4S

Mol. Mass.

500.569

SMILES

Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CC(=O)NS(C)(=O)=O |(10,-36.32,;8.46,-36.32,;7.55,-35.06,;8.32,-33.74,;9.87,-33.75,;10.64,-32.42,;12.18,-32.42,;12.94,-33.76,;12.16,-35.08,;12.93,-36.42,;14.47,-36.43,;15.24,-35.09,;14.48,-33.76,;9.88,-31.08,;10.65,-29.75,;8.33,-31.07,;7.56,-29.74,;6.01,-29.74,;5.24,-31.09,;6.02,-32.42,;7.56,-32.41,;6.08,-35.54,;4.74,-34.78,;3.41,-35.55,;3.41,-37.09,;4.74,-37.86,;6.08,-37.09,;7.55,-37.57,;8.03,-39.04,;7,-40.18,;7.47,-41.65,;5.49,-39.87,;4.46,-41.01,;2.95,-40.7,;5.79,-41.78,;4.45,-42.55,)|

Structure