Ki Summary

Reaction Details

Report a problem with these data

Target

Prostaglandin D2 receptor 2

Ligand

BDBM50401103

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_884446 (CHEMBL2212208)

IC50

>1000±n/a nM

Citation

Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin D2 receptor 2

Name:

Prostaglandin D2 receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

43295.45

Organism:

Homo sapiens (Human)

Description:

Q9Y5Y4

Residue:

395

Sequence:

MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

BDBM50401103

n/a

Name

BDBM50401103

Synonyms:

CHEMBL2205153

Type

Small organic molecule

Emp. Form.

C30H28N4O2

Mol. Mass.

476.5689

SMILES

Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CC(=O)N1CCCC1 |(37.67,-22.1,;36.13,-22.1,;35.22,-20.85,;35.99,-19.52,;37.53,-19.53,;38.31,-18.21,;39.85,-18.21,;40.61,-19.55,;39.83,-20.87,;40.59,-22.2,;42.13,-22.21,;42.91,-20.87,;42.14,-19.54,;37.54,-16.87,;38.32,-15.54,;36,-16.86,;35.23,-15.53,;33.68,-15.53,;32.91,-16.88,;33.69,-18.21,;35.23,-18.2,;33.75,-21.33,;32.41,-20.57,;31.09,-21.34,;31.08,-22.88,;32.42,-23.65,;33.75,-22.88,;35.22,-23.36,;35.7,-24.82,;34.67,-25.96,;35.14,-27.43,;33.16,-25.65,;32.53,-24.25,;31,-24.42,;30.69,-25.92,;32.02,-26.69,)|

Structure