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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prostaglandin D2 receptor 2 | ||
| Ligand | BDBM50401106 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_884446 (CHEMBL2212208) | ||
| IC50 | 16±n/a nM | ||
| Citation |  Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prostaglandin D2 receptor 2 | |||
| Name: | Prostaglandin D2 receptor 2 | ||
| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 43295.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y5Y4 | ||
| Residue: | 395 | ||
| Sequence: |
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| BDBM50401106 | |||
| n/a | |||
| Name | BDBM50401106 | ||
| Synonyms: | CHEMBL2205150 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H21N3O3 | ||
| Mol. Mass. | 423.4632 | ||
| SMILES | Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CC(O)=O |(37.95,-7.39,;36.41,-7.39,;35.5,-6.14,;36.27,-4.81,;37.81,-4.82,;38.59,-3.49,;40.13,-3.5,;40.89,-4.83,;40.11,-6.16,;40.87,-7.49,;42.41,-7.5,;43.19,-6.16,;42.42,-4.83,;37.82,-2.15,;38.6,-.82,;36.28,-2.15,;35.51,-.81,;33.96,-.81,;33.19,-2.16,;33.97,-3.49,;35.51,-3.49,;34.03,-6.62,;32.69,-5.85,;31.36,-6.62,;31.36,-8.17,;32.69,-8.94,;34.03,-8.17,;35.5,-8.65,;35.98,-10.11,;34.95,-11.25,;33.44,-10.94,;35.42,-12.72,)| | ||
| Structure | 
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