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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prostaglandin D2 receptor 2 | ||
| Ligand | BDBM50401124 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_884446 (CHEMBL2212208) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prostaglandin D2 receptor 2 | |||
| Name: | Prostaglandin D2 receptor 2 | ||
| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 43295.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y5Y4 | ||
| Residue: | 395 | ||
| Sequence: |
| ||
| BDBM50401124 | |||
| n/a | |||
| Name | BDBM50401124 | ||
| Synonyms: | CHEMBL2205144 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H20FN3O3 | ||
| Mol. Mass. | 441.4537 | ||
| SMILES | Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2cc(F)ccc2n1CC(O)=O |(8.23,-6.54,;6.69,-6.54,;5.77,-5.29,;6.5,-3.93,;8.04,-3.88,;8.76,-2.52,;10.3,-2.47,;11.12,-3.77,;10.39,-5.13,;11.2,-6.43,;12.75,-6.38,;13.47,-5.01,;12.65,-3.71,;7.94,-1.21,;8.66,.16,;6.4,-1.28,;5.59,.03,;4.05,-.04,;3.34,-1.4,;4.16,-2.69,;5.68,-2.63,;4.3,-5.77,;2.96,-5,;1.63,-5.78,;.3,-5,;1.63,-7.32,;2.96,-8.09,;4.3,-7.32,;5.77,-7.8,;6.49,-9.16,;5.67,-10.47,;4.13,-10.41,;6.39,-11.83,)| | ||
| Structure | 
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