Ki Summary

Reaction Details

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Target

Prostaglandin D2 receptor 2

Ligand

BDBM50401126

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_884446 (CHEMBL2212208)

IC50

11±n/a nM

Citation

Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin D2 receptor 2

Name:

Prostaglandin D2 receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

43295.45

Organism:

Homo sapiens (Human)

Description:

Q9Y5Y4

Residue:

395

Sequence:

MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

BDBM50401126

n/a

Name

BDBM50401126

Synonyms:

CHEMBL2204493

Type

Small organic molecule

Emp. Form.

C26H20ClN3O3

Mol. Mass.

457.908

SMILES

Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2cc(Cl)ccc2n1CC(O)=O |(23.87,-56.05,;22.33,-56.05,;21.42,-54.8,;22.14,-53.44,;23.68,-53.39,;24.41,-52.03,;25.95,-51.98,;26.76,-53.28,;26.03,-54.64,;26.85,-55.94,;28.39,-55.89,;29.11,-54.52,;28.29,-53.22,;23.59,-50.72,;24.31,-49.36,;22.04,-50.79,;21.23,-49.49,;19.7,-49.55,;18.98,-50.91,;19.8,-52.2,;21.32,-52.14,;19.94,-55.28,;18.61,-54.51,;17.28,-55.28,;15.94,-54.51,;17.27,-56.83,;18.61,-57.6,;19.94,-56.83,;21.42,-57.31,;22.14,-58.67,;21.31,-59.98,;19.77,-59.92,;22.03,-61.34,)|

Structure