| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
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| Ligand | BDBM50401916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_886437 (CHEMBL2213809) |
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| IC50 | 130±n/a nM |
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| Citation |  McIver, EG; Bryans, J; Birchall, K; Chugh, J; Drake, T; Lewis, SJ; Osborne, J; Smiljanic-Hurley, E; Tsang, W; Kamal, A; Levy, A; Newman, M; Taylor, D; Arthur, JS; Clark, K; Cohen, P Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg Med Chem Lett22:7169-73 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TBK1 |
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| Name: | Serine/threonine-protein kinase TBK1 |
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| Synonyms: | T2K | TANK-binding kinase 1 | TBK1_MOUSE | Tbk1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83429.25 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_886437 |
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| Residue: | 729 |
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| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFA
ETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLV
LELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTG
VVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQE
GTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSH
FSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQ
KMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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| BDBM50401916 |
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| n/a |
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| Name | BDBM50401916 |
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| Synonyms: | CHEMBL2207211 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N7O |
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| Mol. Mass. | 395.5013 |
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| SMILES | O=C(NCCCNc1nc(Nc2cnn(c2)C2CC2)ncc1C1CC1)C1CCC1 |
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| Structure | 
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