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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402479 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 9±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402479 | |||
| n/a | |||
| Name | BDBM50402479 | ||
| Synonyms: | CHEMBL2204062 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H35N3O2 | ||
| Mol. Mass. | 445.5964 | ||
| SMILES | CN(C)CCn1c(=O)[nH]c([C@@H]2CC[C@@H](CC2)c2ccccc2)c(Cc2cccc(C)c2)c1=O |r,wU:10.9,13.16,(35.07,-8.79,;36.41,-8.02,;36.41,-6.48,;37.74,-8.79,;39.07,-8.02,;40.41,-8.79,;40.41,-10.34,;39.06,-11.13,;41.74,-11.11,;43.08,-10.34,;44.4,-11.11,;44.4,-12.65,;45.71,-13.42,;47.05,-12.66,;47.05,-11.12,;45.72,-10.34,;48.38,-13.44,;49.7,-12.68,;51.03,-13.45,;51.03,-15,;49.69,-15.76,;48.38,-14.98,;43.08,-8.78,;44.41,-8,;44.41,-6.44,;43.09,-5.65,;43.09,-4.11,;44.43,-3.35,;45.78,-4.14,;47.11,-3.37,;45.78,-5.68,;41.76,-8.02,;41.76,-6.48,)| | ||
| Structure | 
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